You want your dog to be vigorous, active and fit long into his senior years, so adding to his regular diet with a nutrient-rich supplement means looking carefully at the ingredients list to determine exactly what your dog is ingesting and why he needs it. We have detailed some of the components of our Muscle Builder & Performance supplement to show you the science behind the supplement so you can make your best healthy choice for your animal.
Dimethylglycine (DMG) is an amino acid, a building block for protein produced and found only in very small amounts in the canine body. According to holistic veterinarian and exotic pet expert Dr. Margaret A. Wissman, DMG “provides useful building units for biosynthesis of vitamins, hormones, neurotransmitters, antibodies, nucleic acids and other metabolically active molecules.”
Dr. Wissman believes that DMG can be used effectively in dogs with a number of health problems including neurological disorders, cardiovascular problems, diabetes mellitus, autoimmune disorders, allergies, liver disease, respiratory issues, cancer and tumors. DMG also appears to enhance oxygen utilization, improve the cardiovascular system by relieving stress, and reduce the recovery time after vigorous exercise.
Cancer Fighter -- In a 2000 paper published by FoodScience Corp., Dr. John Lawson of Clemson University discovered that rabbits given DMG after injections of typhoid or influenza produced four times the number of natural anti-bodies needed to fight the diseases compared to the group of control rabbits not given the DMG. The same group of patients showed a 3 to 9 times greater increase in their T-cell count.
T-cells are the type of white blood cells that play a major role in cell-mediated immunity, the immunity needed to ward off various auto-immune diseases and cancers, including (in humans) the AIDS virus. DMG also doubled the body’s ability to produce interferon, a product of lymphocytes, that enhances the immunity to infections and kills cancer cells.
A study on mice using DMG against the antigen causing melanoma, a highly metastatic form of skin cancer, found that none of the mice given DMG grew primary tumors. Seventy percent of the mice not given the amino acid developed melanoma tumors.
Oxygen Utilization – Oxygen, as well as other chemicals and nutrients, is transported in and out of body cells on a regular basis. How well an oxygen molecule is used by the body can be mediated by a number of factors, including the age and condition of the cellular walls, the ability of the immune system to function properly, and the overall health of the body in question.
An early study published in The Journal of Infectious Diseases by Dr. C. D. Graber, et al. of the University of Southern California found that, when given DMG after an injection of pokeweed allergens, 20 human study subjects increased their antibody response fourfold as compared to the immunity response given the vaccinated control group. He stated that DMG presumably “enhances oxygen utilization by tissue and effectively complexes free radicals.”
In his book How to Boost Your Immune System, author Gary Singh states that, “Sublingual DMG is probably a more effective methyl donor than oral TMG or or DMG. Increased oxygen utilization inside the cells can inactivate intracellular viruses, fungus and bacteria. Folic acid supports an enzyme that breaks down DMG and the breakdown products are likely where the benefits reside. Folic acid supports the process.”
Exercise Recovery – Two studies in the Journal of Animal Science ten years apart, purported to show that the application of DMG on Thoroughbred horses after a strenuous workup lessened the effects of the lactic acid buildup that causes muscle soreness, thus shortening the time for exercise recovery.
While the earlier study stated that the administration of DMG produced no significant differences in the measured values of carbon dioxide production (VCO2), heart rate, arterial blood and plasma lactate concentrations, arterial blood gases and pH, the latter experiment deduced that plasma lactate (lactic acid) levels were lower in untrained horses given DMG than were the levels of the control group of trained horses.
This theory could lead dog owners and trainers to determine that a less-fit animal would be more apt to find DMG supplementation beneficial than a well-exercised dog were it not for the fact that DMG is known for its cancer-fighting and immune-stimulating properties.
GlutaSyn Brand Whey Protein Isolate
Whey protein is a food product/dietary supplement created by separating the components found in milk during the cheese-making process. Whey comes in three forms: whey isolate, whey concentrate, or whey hydrolysate. The whey isolate included in Muscle Builder And Performance supplement contains a higher percentage of pure protein than other types of whey because each protein molecule of the isolate is purified and attached only to other protein molecules. That means it is virtually lactose, carbohydrate, fat, and cholesterol free.
Protein, an essential nutrient, is the main structural element in your dog’s cells. All of the body organs and tissues, including the cells that allow for muscle contraction (the heart and lungs), the collagen found in joints, cartilage, tendons, and ligaments, and the cellular products found in blood (globulin, hemoglobin, and albumin) consist primarily of proteins and amino acids. Without sufficient proteins, the heart stops beating, body temperature becomes de-regulated, and organ systems fail.
Whey proteins, in particular, have extensive antioxidant properties that have been shown to protect against heart disease and to cleanse the liver against toxic residue.
In a 2011 study published in the journal Lipids in Health and Disease, researchers administered high levels whey protein in the form of colostrum (mother’s milk) to animal subjects (rats) for 4 weeks. They found that both cholesterol and triglyceride numbers significantly decreased over the numbers of the control subjects who did not receive the protein. The scientists also discovered that liver values increased, indicating that the toxins that normally filter through the liver system that can cause liver damage and/or failure were having a less detrimental effect on the organ. When the same experiment was performed on human subjects, the results were the same.
KPx Brand Colostrum
Colostrum is the fluid produced in a mother’s mammary glands immediately after birth before the milk comes in. This liquid, that only lasts approximately 4 to 8 hours after delivery, contains the mother’s antibodies and immunoglobulins that provide the newborn with its immune system and growth factors. These elements found in colostrum afford your dog numerous health benefits as it ages and experiences various health challenges.
According to veterinarian Richard H. Pitcairn in his book Dr. Pitcairn's Complete Guide to Natural Health for Dogs & Cats, the benefits of colostrum supplementation for dogs can appear almost limitless. Along with the antibodies that enhance a dog’s immune system, colostrum supplements also contain 17 essential amino acids (the building blocks of muscle and tissue), glyconutrients that encourage the activity of disease-fighting white blood cells, and essential fatty acids that destroy the free radicals that contribute to aging.
Holistic veterinarian Dr. Andrew Jones states that colostrum supplementation can benefit your pet in five important areas.
Protect against medication side effects
Non-steroidal anti-inflammatory drugs (NSAIDs) used to alleviate the pain in dogs with musculoskeletal injuries and chronic arthritis are known to cause gastric bleeding, ulcers, and even stomach and intestinal perforations in animals that use them regularly. In a 2000 study posted in the American Journal of Clinical Nutrition, the growth factors found colostrum supplements were shown to reduce intestinal issues in rats and mice.
Lessen the effects of IBD (Inflammatory Bowel Disease)
Those same growth factors, coupled with whey proteins, appeared to lessen the incidences of colitis and the symptoms of IBD in the test animals.
Benefit the immune system
An article in the 2000 edition of the Canadian Veterinary Journal states that, when used as a nutraceutical (a food/supplement that has medicinal benefits), colostrum increased resistance to infection, killed pathogens in the intestinal tract, helped wounds heal faster, increased the T-cell and B-cell production that destroys toxins, bacteria, and viruses, and increased the absorption of electrolytes and nutrients.
Aid in weight loss
Colostrum increases the basal metabolic rate – the energy levels your body needs for optimal functioning of blood circulation, respiration, adjustment of hormone levels (including insulin and thyroid), and the repair and growth of cells. With an increase in energy comes a decrease in fatty tissue and the emergence of lean muscle mass. That lean muscle mass is what you look for in your GSD or Rottweiler.
Decrease allergy symptoms
According to his research, Dr. Jones believes that the praline-rich polypeptide (PRP) found in bovine colostrum decrease allergy symptoms of itchy skin and paws.
Creatine is a derivative of the amino acids arginine, glycine, and methionine that is formed in the body’s liver, pancreas and kidneys and aids in muscle’s abilities to produce short, intense bursts of energy. Creatine builds lean body mass by allowing the muscles to work longer and train harder.
A recent research study published in The Journal of Nutrition looked at the energy levels expressed in muscles after supplementing the diets of twelve beagles for 4 weeks with creatine. Creatine levels were also checked in the animal’s blood plasma to determine how much of the creatine was being excreted in urine. The scientists discovered that those animals with little muscle mass prior to the creatine ingestion substantially increased energy levels and mass during the study, with the majority of the increase happening within the first 14 days of the trial. Those animals that were already muscular showed little mass increase, but were able to maintain musculature and up energy levels.
The supplements caused increased levels of creatine to be found in blood plasma with an upsurge in urination leading to more creatine being excreted from the body. The study concluded that more research is needed to expand the awareness of creatine metabolism in dogs.
Lecithin is a type of fatty acid that is a major part of all biological membranes, including those of canines. It plays an essential role in the dog’s neurological, reproductive, and digestive systems and is required for optimal cell metabolism. Lecithin is said to increase brain levels of acetylcholine, an organic chemical normally found in the body that acts as a neurotransmitter, resulting in enhanced memory and learning ability and decreasing the risk of neurological disorders.
Additionally, university studies suggest that lecithin supplementation lowers cholesterol levels by stimulating cholesterol metabolism, thus decreasing the risk for the cardiac disease common in the larger dog breeds.
An article in the Journal of Clinical Investigation studied the excretion rates of bile acid, lecithin and cholesterol in the livers of unanesthetized dogs after the blood circulation was clinically stopped in the organs. Statistics showed that both lecithin output and cholesterol output were directly related to bile acid excretion rate.
This lead the researchers to conclude that digestive health, in the form of decreased excretions of bile acids, increased the ratio of lecithin in the body. Because lecithin molecules have been shown to attach to molecules of cholesterol, the scientists concluded that higher levels of lecithin in the body increase the metabolic rate of cholesterol. This forces cholesterol out of the cellular components of the circulatory system where it tends to gather and cause heart disease.
Amino acids are the organic compounds that compose the building blocks of protein.
They give body cells their structure, play an important role in the transport and storage of nutrients and influence the function of organs, tendons, arteries, and glands. Amino acids have been shown to aid in the healing of wounds and reparation of tissue. Additionally, they aid in the removal of toxins produced during energy metabolism. The three most important amino acids contained in Muscle Builder & Performance are Methionine, Lysine, and Carnitine.
- DL-Methionine holds connective tissues and proteins together in compounds called “disulfide bonds.” It is important in the formation of cartilage, strengthens bones, hair, and nails, and works to combat hair loss.
- L-Lysine supports the absorption of calcium (important in bone and cardiac health), the production of collagen, and the building of muscle proteins. Lysine is important for proper growth, and it plays an essential role in the production of carnitine, a nutrient responsible for converting fatty acids into energy and helping lower cholesterol.
- L-Carnitine transports fatty acids into the inner part of the cell so they can be oxidized ("burned") to produce energy. It also carries the toxic compounds generated by this metabolic process out of the cell and prevents their accumulation. Because of this oxidation process, carnitine makes for a leaner canine body by decreasing body fat in favor of muscle proteins.